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Zhaoduo Zhang, Ph.D.
I am interested in understanding gene function and protein-protein interaction using high through-put genomic and proteomic techniques, such as microarray, 2-D fluorescence difference gel electrophoresis (DIGE), phage display. I am also interested in developing novel techniques specifically applicable to protein research.

Current research topics:

  • Identifying abundant constitutively expressed proteins in Francisella novicida cultured at various media using 2-dimensional gel electrophoresis and mass spectrometry.
  • Developing a novel shotgun protein sequencing technique based on the multiple enzymatic digestion of a protein or protein mixture that reconstructs protein sequences from sequences of overlapping peptides.

Recent Publications

Gonzales, A. D., Light, Y. K., Zhang, Z., Iqbal, T., Lane, T. W. & Martino. A. (2005) "Proteomic analysis of the CO2-concentrating mechanism in the open-ocean cyanobacterium Synechococcus WH8102." Canadian Journal of Botany 83(7): 735–745.

Zhang, Z., Shrager, J., Jain, M., Chang, C. W., Vallon, O. & Grossman. A. R. (2004) "Insights into the survival of Chlamydomonas reinhardtii during sulfur starvation based on microarray analysis of gene expression." Eukaryotic Cell 3(5): 1331-1348.
PubMed

Grossman, A. R., Harris, E. E., Hauser, C., Lefebvre, P. A., Martinez, D., Rokhsar, D., Shrager, J., Silflow, C. D., Stern, D., Vallon, O. and Zhang. Z. (2003) "Chlamydomonas reinhardtii at the crossroads of genomics." Eukaryotic Cell 2(6): 1137-1150.
PubMed

Shrager, J., Chang, C.-W., Hauser, C., Harris, E., Tamse, R., Davies, J., Zhang, Z. & Grossman. A. R. (2003) "Chlamydomonas reinhardtii genome project: A guide to the generation and use of the cDNA information." Plant Physiology 131: 401-408.
PubMed

Im, C-S., Zhang, Z. & Grossman. A. R. (2003) "Analysis of light and CO2 regulation in Chlamydomonas reinhardtii using genome-wide approaches." Photosynthesis Research 75: 111-125.

Zhang, Z., Cavalier-Smith T. & Green. B. R. (2002) "Evolution of dinoflagellate minicircles and the partially concerted divergence of their putative replicon origins." Molecular Biology and Evolution 19: 489-500.
PubMed

Zhang, Z., Cavalier-Smith T. & Green. B. R. (2001) "A family of selfish minicircular chromosomes with jumbled gene fragments in a dinoflagellate chloroplast." Molecular Biology and Evolution 18:1558-1565.
PubMed

Zhang, Z., Green. B. R. & Cavalier-Smith T. (2000) "Phylogeny of ultra-rapidly evolving dinoflagellate chloroplast genes suggests a common origin for sporozoan and dinoflagellate plastids." Journal of Molecular Evolution 51: 26-40.
PubMed

Zhang, Z., Green. B. R. & Cavalier-Smith T. (1999) "Single gene circles in dinoflagellate chloroplast genomes." Nature 400:155-159.
PubMed


Appointments

2003-present: Postdoctoral Fellow, Sandia National Laboratories, Livermore CA
2000-2002: Research Associate, Carnegie Institution of Washington, Department of Plant Biology, Stanford, CA
1988-1995: Lecturer, Department of Biology, Hebei Teacher’s University, China
1983-1985: Teacher, Taizhi High School, Hubei, China


Education

1995-2000: Ph.D., Dept. of Botany, University of British Columbia, Vancouver, BC, Canada
1985-1988: M.S., Department of Biology, Hebei Teacher’s University, Hebei, China
1979-1983: B.S., Department of Biology, Huazhong Teacher’s University, Hubei, China


Contact Information

Dr. Zhaoduo Zhang
Biosystems Research Department
Sandia National Laboratories
MS 9292, PO Box 969
7011 East Avenue
Livermore, CA 94551-0969

zzhang@sandia.gov
phone: 925-294-2513
fax: 925-294-3020