Summary of Professional Experience

Victoria VanderNoot has been with Sandia National Laboratories for nearly a decade, with almost 15 years of technology based research experience. Her research interests focus on biochemical and bioanalytical methods for environmental, biomedical and biodefense applications with an emphasis on optical, microfluidic and biosensor technologies. She most recently served as PI in a Cooperative Research and Development Agreement with Tenix Investments, Pty to develop a water monitoring system for protein toxins in domestic water and has been funded through NOAA’s CICEET to develop electrophoretic methods for marine toxins. She has also been heavily involved with developing and testing technologies for aerosol and aqueous based monitoring for bacterial agents and toxins in a Department of Defense funded effort and is co-PI and project manager on a project developing electrophoretic methods for the determination of biomarkers of disease in saliva (NIH, NIDCR).

Recent Projects

Development of a stand-alone autonomous microfluidic platform for domestic water monitoring. Participated in extensive testing of prototypes at two domestic water utility stations (in CA and AZ).

Development of electrophoretic separation methods for a select suite of marine toxins in a one-year proof-of-concept CICEET funded project. Demonstrated the successful separation of domoic acid, saxitoxin and neosaxtitoxin and successful fluorescent labeling and sensitive detection of domoic acid in microfluidic chip platform

Developed methods for rapid spore detection via analysis of small acid soluble proteins (SASPs) and rapid determination of viability via analysis of early germination de novo protein synthesis in a microfluidic approach

Development of an automated platform for monitoring of aerosol borne microbial agents. Developed methodology that was adapted to the microfluidic sample preparation train. Participated in in-situ testing of prototypes at multiple DoD facilities

Development of technologies for disease biomarker detection in saliva. Project manager for $4.2 M effort; award was first competitive grant (U01) from NIH at Sandia National Laboratories (NIH/NIDCR)

Selected Publications

Autonomous Microfluidic Sample Preparation System for Protein Profile-Based Detection of Aerosolized Bacterial Cells and Spores, Jeanne C. Stachowiak, Erin E. Shugard, Bruce P. Mosier, Ronald F. Renzi, Pamela F. Caton, Scott M. Ferko, James L. Van de Vreugde, Daniel D. Yee, Brent L. Haroldsen, Victoria A. VanderNoot, (2007) Analytical Chemistry, 79, 5763 -5770.

Bacterial Characterization Using Protein Profiling in an Integrated Microchip Separations Platform, Shelly A. Pizarro, Pamela Lane, Todd W. Lane, Evelyn Cruz, Brent Haroldsen and Victoria A. VanderNoot Electrophoresis, in press.

Julia A. Fruetel, Ronald F. Renzi, Victoria A. VanderNoot, James Stamps, Brent A. Horn, Jay A. A. West, Scott Ferko, Robert Crocker, Christopher G. Bailey, Don Arnold, Boyd Wiedenman, Wen-Yee Choi, Daniel Yee, Isaac Shokair, Ernest Hasselbrink, Philip Paul, David Rakestraw, and Debbie Padgen, Microchip Separations of Protein Biotoxins Using an Integrated Hand-held Device, (2005) Electrophoresis, 26, 1144 – 1154.

Ronald F. Renzi, James Stamps, Brent A. Horn, Scott Ferko, Victoria A. VanderNoot, Jay A.A. West, Robert Crocker, Boyd Wiedenman, Daniel Yee and Julia A. Fruetel, Hand-Held Microanalytical Instrument for Chip-Based Electrophoretic Separations of Proteins, (2004) Analytical Chemistry, 77, 435-441.

M. VanRollins and V.A. VanderNoot, Simultaneous Resolution of Underivatized Regioisomers and Stereoisomers of Arachidonate Epoxides by Capillary Electrophoresis Analytical Biochemistry, (2003), 313, 106-116.

Victoria A. VanderNoot and Mike VanRollins, Capillary Electrophoresis of Cytochrome P-450 Epoxygenase Metabolites of Arachidonic Acid. 2. Resolution of Stereoisomers Analytical Chemistry, (2002), 74, 5866-5870.

Victoria A. VanderNoot and Mike VanRollins, Capillary Electrophoresis of Cytochrome P-450 Epoxygenase Metabolites of Arachidonic Acid. 1. Resolution of Regioisomers Analytical Chemistry, (2002), 74, 5859-5865.

V. A. VanderNoot, G. Hux, J. Schoeniger and T. Shepodd, Isoelectric Focusing Using Electrokinetically-generated Pressure Mobilization. µTAS 2001. J. Michael Ramsey and A. van den Berg. ed.s, (Kluwer Academic, Amsterdam), (2001), pp. 127-128.

M. Fath, V. A. VanderNoot, Ilkka Kilpeläinen, Tarja Kinnunen, Heikki Rauvala and R. J. Linhardt, Interaction of Soluble and Surface-bound Heparin Binding growth-associated Molecule with Heparin. FEBS Letters, (1999), 454, 105-108.

I. Capila, V.A. VanderNoot, T.R. Mealy, B.A. Seaton, R.J. Linhardt, Interaction of Heparin with Annexin V. FEBS Letters, (1999), 446, 327-330.

E.E.O. Caldwell, A.M. Andreasen, M.A. Blietz, J.N. Serrahn, V.A. VanderNoot, Y. Park, G.Y. Yu, R.J. Linhardt, J.M. Weiler Heparin Binding and Augmentation of C1 Inhibitor Activity. Archives of Biochemistry and Biophysics, (1999), 361, 215-222.

J. H. Choe, V. A. VanderNoot, R. J. Linhardt and J. S. Dordick, Affinity-based Reversed Micellar Extraction and Separation (ARMES) to Resolve Structurally Similar Glycoproteins. AICHE Journal, (1998), 44, 2542-2548.

V. A. VanderNoot, R. E. Hileman, J. S. Dordick and R. J. Linhardt, Capillary Electrophoresis Employing Immobilized Glycosaminoglycan to Resolve Heparin-binding Peptides. Electrophoresis, (1998), 19, 437-441.

Edward P. C. Lai, Ania Farfara, Victoria A. VanderNoot, Mari Kono and Brandee Polsky, Surface Plasmon Resonance Sensors Using Molecularly Imprinted Polymers for Sorbent Assay of Theophylline, Caffeine and Xanthine, Canadian Journal of Chemistry, (1998), 76, 265-273.

J. H. Choe, V. A. VanderNoot, R. J. Linhardt and J. S. Dordick, Parameters Affecting the Affinity Based Reversed Micellar Extraction and Separation of Glycoproteins. Biotechnology Progress, (1997), 13, 440-445.

C.L. Chakrabarti, B. Marchand, V. A. VanderNoot, J. Walker and W.H. Schroeder, Development Of A New Method For Direct Determination Of Selenium Associated With Atmospheric Particulate Matter Using Chemical Modifiers And Graphite Probe Furnace Atomic-Absorption. Spectrochimica Acta Part B-Atomic Spectroscopy, (1996), 51, 155-163.

V. A. VanderNoot and F. A. Fitzpatrick, Competitive Binding Assay of Src Homology 3 Interactions Between 5-Lipoxygenase and Growth Factor Receptor Binding Protein-2. Analytical Biochemistry, (1995), 230, 108-114.

D. A. Berg, V. A. VanderNoot, R. G. Barradas and E. P. C. Lai, In-Situ Photoacoustic Determination of Thallium Underpotential Deposition on Copper. Journal of Electroanalytical Chemistry, (1994), 369, 33-37.

E. P. C. Lai, B. Wong and V. A. VanderNoot, Preservation of Solid Mercuric Dithizonate Samples with Polyvinyl Chloride For Determination of Mercury (II) in Environmental Waters by Photochromism-induced Photoacoustic Spectrometry. Talanta, (1993), 70, 1097-1105.

V. A. VanderNoot and E. P. C. Lai, Determination of Mercury (II) in Dithizone-impregnated Latex Microparticles by Photochromism-induced Photoacoustic Spectroscopy. Analytical Chemistry, (1992), 64, 3187-3190.

V A. VanderNoot and E. P. C. Lai, Detecting Surface Plasmon Resonance Using Photothermal Deflection Spectroscopy: Development of an Optical Immunosensor. Spectroscopy, (1991), 6(7), 28-33.

Patent

U.S. Patent Application No. 10/633,871, Portable Apparatus for Separating Sample and Detecting Target Analytes, Sandia Reference # SD-8412.1 Julia A. Fruetel, Victoria VanderNoot, Brent A Horn, Jay A.A. West, Ronald Renzi, Scott Ferko, James F. Stamps, Isaac R. Shokair, Daniel Yee, Robert Crocker, Boyd Wiedenman