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Joseph S. Schoeniger, M.D. Ph.D. |
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| At SNL/CA I have established programs to develop biosensors, bioanalytical
instrumentation and co-founded a new major facility, the Chemical and
Radiation Detector Laboratory. Projects I have initiated include
development of organophospate sensor based on enzyme coated ion-sensitive
field effect transistors, use of sol-gel techniques for improved fiber-
optic sensors, development of ultrasensitive fluorescence-based assays
for biotoxins using self-assembled materials, affinity electrochromatography
with LIF detection, microelectrode array-based sensors for pathogen detection,
and the use of combinatorial chemical synthesis and computational design of
molecular recognition materials for sensor and antitoxin development.
Recently, my research activities, funded by DOE and other government sponsors, have focused on the development of novel microseparations methods for proteins, peptides and DNA, and the intersection of these methods with classical protein chemistry, as well as analytical methods such as high-resolution mass spectrometry, for solving outstanding problems in proteomics and structural genomics. |
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Recent PublicationsSlade, AL; Schoeniger, JS; Sasaki, DY; Yip, CM. In situ scanning probe microscopy studies of tetanus toxin-membrane interactions. Biophysical Journal; 2006; v.91, no.12, p.4565-4574 Jacobsen, RB; Sale, KL; Ayson, MJ; Novak, P; Hong, JH; Lane, P; Wood, NL; Kruppa, GH; Young, MM; Schoeniger, JS. Structure and dynamics of dark-state bovine rhodopsin revealed by chemical cross-linking and high-resolution mass spectrometry Protein Science; 2006; v.15, no.6, p.1303-1317 Novak, P; Haskins, WE; Ayson, MJ; Jacobsen, RB; Schoeniger, JS; Leavell, MD; Young, MM; Kruppa, GH. Unambiguous assignment of intramolecular chemical cross-links in modified mammalian membrane proteins by Fourier transform-tandem mass spectrometry. Analytical Chemistry; Aug 15 2005; v.77, no.16, p.5101-5106 Zhou, CLE; Zemla, AT; Roe, D; Young, M; Lam, M; Schoeniger, JS; Balhorn, R.
"Computational approaches for identification of conserved/unique binding pockets
in the A chain of ricin." Bioinformatics, (2005), 21(14), 3089-3096 Leavell MD, Novak P, Behrens CR, Schoeniger JS, Kruppa GH.
"Strategy for selective chemical cross-linking of tyrosine and lysine residues." J Am Soc Mass Spectrom. 2004 Nov;15(11):1604-11. Sale K, Faulon JL, Gray GA, Schoeniger JS, Young MM.
"Optimal bundling of transmembrane helices using sparse distance constraints." Protein Sci. 2004 Oct;13(10):2613-27 Wang G, De J, Schoeniger JS, Roe DC, Carbonell RG.
"A hexamer peptide ligand that binds selectively to staphylococcal enterotoxin B:
isolation from a solid phase combinatorial library." J Pept Res. 2004 Aug;64(2):51-64. Fujii, N; Jacobsen, RB; Wood, NL; Schoeniger, JS; Guy, RK.
"A novel protein crosslinking reagent for the determination of moderate
resolution protein structures by mass spectrometry (MS3-D)."
Bioorganic & Medicinal Chemistry Letters, (2004), 14(2), 427-429. Novak P, Kruppa GH, Young MM, Schoeniger JS.
"A top down method for the determination of residue specific solvent accessibility in
proteins." J Mass Spectrom 39:322-328. 2004.
Novak P, Young MM, Schoeniger JS, Kruppa GH.
"A top-down approach to protein structure studies using chemical cross-linking and
Fourier transform mass spectrometry." Eur J Mass Spectrom (Chichester, Eng). 2003;9(6):623-31. Kruppa GH, Schoeniger JS, Young MM. "A Top Down Approach to Protein Structural Studies Using Chemical Cross-linking and Fourier Transform Tandem Mass Spectrometry." Rapid Comm Mass Spectrom 17(2):155-162. 2003. Simonian AL, Grimsley JK, Flounders AW, Schoeniger JS, Cheng TC, DeFrank, JJ, Wild, JR. "Enzyme-based biosensor for the direct detection of fluorine-containing organophosphates." Analytica Chimica Acta, (2001), 442(1), 15-23 Singh AK, Harrison SH, Schoeniger JS. "Gangliosides as receptors for
biological toxins: development of sensitive fluoroimmunoassays
using ganglioside-bearing liposomes." Anal Chem 72(24):6019-24. 2000. Singh AK, Flounders AW, Volponi JV, Ashley CS, Wally K, Schoeniger JS. "Development
of sensors for direct detection of organophosphates. Part I: Immobilization,
characterization and stabilization of acetylcholinesterase and organophosphate
hydrolase on silica supports." Biosens Bioelectron 14(8-9):703-13. 1999. Flounders AW, Singh AK, Volponi JV, Carichner SC, Wally K, Simonian AS, Wild JR, Schoeniger JS. "Development of sensors for direct detection of organophosphates. Part II:
Organophosphate hydrolase immobilized to sol-gel coated field effect transistors." Biosens Bioelectron 14(8-9):715-722. 1999. Singh AK, Schoeniger JS, Carbonell RG. "Liposomes as Signal-Enhancement Agents in
Immunodiagnostic Applications" in Biosensors and Their Applications; V.C. Yang
and T.T. Ngo, Eds.; Kluwer Academic/Plenum Publishing: New York, 1999. pp. 131-145. Thomas DH, Rakestraw DJ, Schoeniger JS, Lopez-Avila V, Van Emon J. "Selective
trace enrichment by immunoaffinity capillary electrochromatography on-line with
capillary zone electrophoresis - laser-induced fluorescence." Electrophoresis 20(1):57-66. 1999. Kao HP, Yang N, Schoeniger JS. "Enhancement of evanescent fluorescence from fiber optic
sensors by thin film sol gel coatings." J Op Soc Amer A 15:2163-2171. 1998. Kao HP, Schoeniger JS. "Elliptic trough reflector for the collection of light from linear
sources." Appl Optics 37:4194-4199. 1998. Kao HP, Schoeniger JS. "Hollow cylindrical wave-guides for use as evanescent fluorescence-based
sensors: Effect of numerical aperture on collected signal." Appl Optics 36:8199-8205. 1997. Hsu EW, Schoeniger JS, Bowtell R, Aiken NR, Horsman A, Blackband SJ.
"A modified imaging sequence for accurate T2 measurements using NMR microscopy." J Magn Reson B 109(1):66-9. 1995. O'Dell WG, Schoeniger JS, Blackband SJ, McVeigh ER. "A modified quadrupole
gradient set for use in high resolution MRI tagging." Magn Reson Med 32(2):246-50. 1994. Schoeniger JS, Blackband SJ. "The design and construction of a NMR microscopy probe." J Magn Reson B 104(2):127-34. 1994. Schoeniger JS, Aiken N, Hsu E, Blackband SJ. "Relaxation-time and diffusion NMR
microscopy of single neurons." J Magn Reson B 103(3):261-73. 1994.
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Contact Information Dr. Joseph S. Schoeniger jsschoe@sandia.gov |
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