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Amy E. Herr, Ph.D. |
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My research interests involve understanding the physics and biology of micro-scale biochemical analysis techniques and associated fluid mechanics. I am interested in characterization and development of high throughput, sensitive, efficient bioanalysis techniques involving MEMS technologies and the life and physical sciences. Such techniques are capable of assessing systemic health and disease states, thus permitting new detection, prevention and therapeutic strategies.
I am particularly interested in microsystems that enable the study of proteins (expression levels, activities, regulation and interactions). My doctoral work involved development of a micro-scale two-dimensional electrophoretic separation for identification and quantification of proteins present in complex samples. I am currently principal investigator on a project seeking to further microscale/microarray technologies for proteomic applications. Additionally, I am involved with an NIH/NIDCR sponsored-project geared towards development of micro-scale methods for multi-analyte detection in oral fluids. The composition of oral fluids correlates with levels of therapeutic, hormonal, immunological, and toxicological molecules -- thus, allowing monitoring for exposure to chemical substances such as biowarfare agents. My work involves development of optical flow diagnostics (e.g., laser induced fluorescence, caged fluorescence imaging), assay development, and microfluidic system design/fabrication. | ||||||||||||
Recent PublicationsA.E. Herr, A.V. Hatch, D.J. Throckmorton, H.M. Tran , J.S. Brennan, W.V. Giannobile, A.K. Singh. "Microfluidic Immunoassays as Rapid Saliva-based Clinical Diagnostics." Proc Natl Acad Sci USA, 2007, 104(13), 5268-5273. PDF file AV Hatch, AE Herr, DJ Throckmorton, JS Brennan, and AK Singh. "Integrated Preconcentration SDS-PAGE of Proteins in Microchips Using Photopatterned Cross-Linked Polyacrylamide Gels." Anal Chem, 2006, 78(14), 4976 - 4984.
VC Rucker, KL Havenstrite, BA Simmons, SM Sickafoose, AE Herr, R Shediac.
"Functional Antibody Immobilization on 3-Dimensional Polymeric Surfaces Generated by
Reactive Ion Etching."
Langmuir, 2005, 21(17), 7621-7625.
VC Rucker, KL Havenstrite, AE Herr.
"Antibody Microarrays for Native Toxin Detection."
Anal Biochem., 2005, 339(2), 262-270.
AE Herr, DJ Throckmorton, AA Davenport, AK Singh.
"On-chip Native Gel Electrophoresis-Based Immunoassays for Tetanus Antibody and Toxin."
Anal Chem., 2005, 77(2), 585-590.
AE Herr, AK Singh.
"Photopolymerized cross-linked polyacrylamide gels for on-chip protein sizing."
Anal Chem., 2004, 76(16), 4727-33.
AE Herr, JI Molho, KA Drouvalakis, JC Mikkelsen, PJ Utz, JG Santiago,
TW Kenny, "On-Chip Coupling of Isoelectric Focusing and Free Solution
Electrophoresis for Multi-Dimensional Separations,"
Anal Chem., 2003, 75(5), 1180-1187.
F Raisi, P Belgrader, DA Borkholder, AE Herr, GJ Kintz, F Pourhamadi,
MT Taylor, MA Northrup, "Microchip Isoelectric Focusing Using a Miniature
Scanning Detection System",
Electrophoresis., 2001, 22(11), 2291-2295.
JI Molho, AE Herr, BP Mosier, JG Santiago, TW Kenny, RA Brennen, GB Gordon,
B Mohammadi. "Optimization of Turn Geometries for Microchip Electrophoresis,"
Anal Chem. 2001, 73(6),1350-1360.
AE Herr, JI Molho, JG Santiago, MG Mungal, TW Kenny, MG Garguilo.
"Electroosmotic Capillary Flow with Nonuniform Zeta Potential."
Anal Chem., 2000, 72(5), 1053-1057.
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Employment2004–present: Senior Member of the Technical Staff, Sandia National Laboratories, Livermore, CA 2002–2004: Research Scientist, Sandia National Laboratories, Livermore, CA |
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Education
1999–2002: Ph.D. Mechanical Engineering,
Stanford University, Stanford, CA 1997–1999: M.S. Mechanical Engineering,
Stanford University, Stanford, CA 1993–1997: B.S. Engineering & Applied Science, Caltech, Pasadena, CA
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Service2007 — Conference Vice-Chair, Gordon Research Conference on the Physics & Chemistry of Micro- and Nano-fluidics (Elected position) 2007 — Americas' Technical Program Committee, 14th International Conference on Solid-State Sensors, Actuators, and Microsystems (Transducers), Lyon, France 2006 — Session Organizer & Chair, American Institute of Chemical Engineers (AIChE) Annual Meeting, San Francisco, CA. 2006 — Session Organizer & Chair, LabAutomation 2006 Conference, Palm Springs, CA 2005 — Americas' Technical Program Committee & Session Chair, 13th International Conference on Solid-State Sensors, Actuators, and Microsystems (Transducers), Seoul, South Korea 2005 — Session Organizer & Chair, LabAutomation Conference, San Jose, CA 2003 — Session Chair, Micro Total Analysis Systems (uTAS) Conference, Squaw Valley, CA Technical Reviewer for the journals: Analytical Chemistry, Electrophoresis, Journal of Microelectromechanical Systems (JMEMS) and the funding agencies: National Science Foundation (2004, 2005, 2006), Army Research Office (2005), Department of Energy (2005) Honors 2007 — US National Academy of Sciences "Frontiers in Science" Symposium attendee (invited) 2007 — Lockheed Martin NOVA Award finalist for Individual Technical Excellence (sole Sandia Nominee) 2007 — Sandia National Laboratories' Employee Recognition Award: Individual Technical Excellence (1 of 11 awarded) 2006 — Sandia National Laboratories' Employee Recognition Award: Oral Diagnostics Team 2005 — 'Innovation Award' Finalist, LabAutomation 2005 (top 10% of podium presentations) 1997–2000 — National Science Foundation Graduate Research Fellowship 1996–1997 — Bibi Jentoft-Nilsen Memorial Leadership Award 1996–1997 — Institute for the Advancement of Engineering – College of Fellows: Outstanding Engineering Student 1994–1997 — Wasserman Educational Endowment Scholarship 1995–1996 — McLean Brothers' Scholarship 1995–1996 — Los Angeles Philanthropic Foundation's Scholarship |
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Contact Information
Dr. Amy E. Herr
aeherr@sandia.gov |
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