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Anson V. Hatch, Ph.D. |
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| My current research interests include developing "lab on a chip" technology for the rapid separation and detection of proteins and other biomarkers for early detection of disease. I am currently working with a team to develop a hand-held device for early detection of periodontal disease using a drop of saliva. One focus has been on developing photopolymerized size-exclusion membranes to fractionate and concentrate proteins. We are now using size-exclusion membranes to preconcentrate proteins on chip prior to polyacrylamide gel electrophoresis immunoassays for rapid detection of low-abundance protein markers in saliva. I am also interested in combining multiple chip-based separation techniques with size-exclusion traps for high resolution separation of low abundance proteins with continuous sampling. | ||||||||||||
Recent PublicationsA.E. Herr, A.V. Hatch, D.J. Throckmorton, H.M. Tran , J.S. Brennan, W.V. Giannobile, A.K. Singh. "Microfluidic Immunoassays as Rapid Saliva-based Clinical Diagnostics." Proc Natl Acad Sci USA, 2007, 104(13), 5268-5273. PDF file AV Hatch, AE Herr, DJ Throckmorton, JS
Brennan, and AK Singh. "Integrated Preconcentration SDS-PAGE of Proteins in
Microchips Using Photopatterned Cross-Linked Polyacrylamide Gels." Anal Chem,
2006, 78(14), 4976 - 4984.
Garcia E, Kirkham JR, Hatch A, Hawkins KR, Yager P.
“Controlled Microfluidic Reconstitution of Functional Protein from an Anhydrous Storage Depot”,
Lab on a Chip, 4(1): 78-82, 2004.
Hatch A, Kamholz AE, Holman G, Yager P, Bohringer KF. “A Ferrofluidic Magnetic Micropump”. Journal of Microelectromechanical Systems, 10 (2): 215-221, 2001.
Hatch A, Kamholz AE, Hawkins KR, Munson MS, Schilling EA, Weigl BH, Yager P.
“Microfluidic Diffusion-Based Analysis: Immunoassay in a T-Sensor”.
Nature Biotechnology, 19(5): 461-465, 2001.
Hatch A, Sano T, Misasi J, Smith CL. “Rolling circle amplification of DNA immobilized on solid surfaces and its application to multiplex mutation detection”. Genetic Analysis – Biomolecular Engineering, 15 (2): 35-40, 1999.
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Contact Information
Dr. Anson V. Hatch
ahatch@sandia.gov |
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